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Gastroenterology Top Stories of 2009: Most Read
CLINICAL PRACTICE GUIDELINE WATCH
Consensus Guidelines for Long-Term NSAID Use
- April 10, 2009
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
A panel of experts developed an algorithm to guide the use of NSAIDs in patients with different gastrointestinal and cardiovascular risks.
- Reviewing:
- Rostom A et al. Aliment Pharmacol Ther 2009 Mar 1; 29:481
SUMMARY AND COMMENT
Predicting Mortality in Patients with Severe Acute Pancreatitis
- September 18, 2009
- Stuart Sherman, MD
- Gastroenterology
A simple new scoring system proved both sensitive and specific for mortality.
- Reviewing:
- Singh VK et al. Am J Gastroenterol 2009 Apr; 104:966
SUMMARY AND COMMENT
Nighttime GERD Has Daytime Consequences
- March 20, 2009
- David A. Johnson, MD
- Gastroenterology
Nighttime GERD, even without reported symptoms of heartburn and regurgitation, can significantly impair sleep.
- Reviewing:
- Orr WC et al. Clin Gastroenterol Hepatol 2008 Oct; 6:1099
SUMMARY AND COMMENT
Proton-Pump Inhibitors and Clopidogrel: Bad Company?
- March 6, 2009
- JoAnne M. Foody, MD, and M. Brian Fennerty, MD
- Gastroenterology
In a large observational cohort of ACS patients, this drug combination was associated with poorer outcomes than was clopidogrel alone.
- Reviewing:
- Ho PM et al. JAMA 2009 Mar 4; 301:937
SUMMARY AND COMMENT
Capsule Endoscopy vs. Colonoscopy for Detecting Colonic Lesions
- July 17, 2009
- Douglas K. Rex, MD
- Gastroenterology
With colonoscopy as the standard of comparison, a new capsule endoscopy system adequately imaged the colon and rectum in 93% of patients.
- Reviewing:
- Van Gossum A et al. N Engl J Med 2009 Jul 16; 361:264
SUMMARY AND COMMENT
Predicting Response to Hepatitis B Virus Therapy
- August 7, 2009
- Atif Zaman, MD, MPH
- Gastroenterology
Hepatitis B virus surface antigen levels during and after pegylated interferon alfa-2a therapy might be predictors of sustained virologic response.
- Reviewing:
- Moucari R et al. Hepatology 2009 Apr; 49:1151
Brunetto MR et al. Hepatology 2009 Apr; 49:1141
SUMMARY AND COMMENT
Telaprevir Shows Promise for HCV, but Concerns Remainn
- April 29, 2009
- Atif Zaman, MD, MPH
- Gastroenterology
Telaprevir’s improved SVR rates will need to be weighed against the complexity of the regimen, development of resistance, and higher discontinuation rates.
- Reviewing:
- McHutchison JG et al. N Engl J Med 2009 Apr 30; 360:1827
Hézode C et al. N Engl J Med 2009 Apr 30; 360:1839
Hoofnagle JH N Engl J Med 2009 Apr 30; 360:1899
SUMMARY AND COMMENT
Low-Dose or High-Dose PPI for Bleeding Peptic Ulcers?
- February 20, 2009
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
- Gastroenterology
Recent study findings indicate that low-dose proton-pump inhibitor therapy might be as effective as high-dose therapy in preventing rebleeding from peptic ulcers after endoscopic therapy.
- Reviewing:
- Andriulli A et al. Am J Gastroenterol 2008 Dec; 103:3011
SUMMARY AND COMMENT
Antidepressants and Upper Gastrointestinal Bleeding
Risks for bleeding were increased with selective serotonin reuptake inhibitors but mitigated by proton-pump inhibitors.
- Reviewing:
- Targownik LE et al. Am J Gastroenterol 2009 Jun; 104:1475
SUMMARY AND COMMENT
Optimal Therapy for UGIB
Endoscopic monotherapy or combination therapy reduces risk for upper gastrointestinal bleeding more than epinephrine alone.
- Reviewing:
- Laine L and McQuaid KR. Clin Gastroenterol Hepatol 2009 Jan; 7:33
