Early Endoscopy for Older Patients with Bleeding Peptic Ulcers
SUMMARY AND COMMENT
Compared with delayed endoscopies, early procedures were associated with shorter hospital stays and lower rates of surgery.
Reviewing:
Cooper GS et al., Gastrointest Endosc 2009 Aug; 70:229
Does Coagulation Status Predict Band-Ulcer Bleeding After Band Ligation?
SUMMARY AND COMMENT
Neither standard nor expanded coagulation indices were predictive.
Reviewing:
Vieira da Rocha EC et al., Clin Gastroenterol Hepatol 2009 Sep; 7:988
PPIs and Clopidogrel: Data Trumps Fear
SUMMARY AND COMMENT
Antiplatelet function was diminished in PPI users, but cardiovascular outcomes were similar in PPI users and nonusers.
CME
Reviewing:
O'Donoghue ML et al., Lancet 2009 Sep 19; 374:989
Genetic Variation and Treatment Response in Hepatitis C Patients
SUMMARY AND COMMENT
A genetic polymorphism helps explain why whites tend to have higher rates of response to HCV treatment than blacks.
CME
Reviewing:
Ge D et al., Nature 2009 Sep 17; 461:399
Endoscopy for Evaluation of Dyspepsia
SUMMARY AND COMMENT
Endoscopy detected few malignant lesions but still might merit the cost in patients aged 50 or older.
Reviewing:
Vakil N et al., Clin Gastroenterol Hepatol 2009 Jul; 7:756
Which Pancreatic Duct Stent Is Best in Patients at Risk for Post-ERCP Pancreatitis?
SUMMARY AND COMMENT
A randomized comparison of 5Fr and 3Fr stents is less than conclusive.
Reviewing:
Chahal P et al., Clin Gastroenterol Hepatol 2009 Aug; 7:834
H. pylori Eradication and Risk for Gastric Cancer
SUMMARY AND COMMENT
Risk reduction was questionable in a meta-analysis of six studies.
Reviewing:
Fuccio L et al., Ann Intern Med 2009 Jul 21; 151:121
Are OTC Analgesics Safe for Patients with Cirrhosis?
SUMMARY AND COMMENT
Occasional low doses of acetaminophen seemed to be safe; the case for NSAIDs was less clear.
Reviewing:
Khalid SK et al., Clin Gastroenterol Hepatol 2009 Sep; 7:994
N -Acetylcysteine for Nonacetaminophen Acute Liver Failure?
SUMMARY AND COMMENT
NAC improved transplant-free survival in patients at coma grades I–II.
Reviewing:
Lee WM et al., Gastroenterology 2009 Sep; 137:856
Water Infusion vs. Air Insufflation During Colonoscopy
SUMMARY AND COMMENT
Warm-water infusion was associated with fewer medication doses, better pain scores, and shorter recovery time.
Reviewing:
Leung JW et al., Gastrointest Endosc 2009 Sep; 70:505