Gastroenterology: Archives

SUMMARY AND COMMENT

Fibrosis Progression in Patients with Hepatitis C Infection

• November 20, 2009
• Atif Zaman, MD, MPH

A gene-based cirrhosis risk score predicted liver fibrosis progression in male patients.

• Reviewing:
• Marcolongo M et al., Hepatology 2009 Oct; 50:1038

SUMMARY AND COMMENT

Interleukin-10 Receptor Mutations and Severe Inflammatory Bowel Disease

• November 20, 2009
• Douglas K. Rex, MD

Mutations in the IL-10 receptor were associated with severe infancy-onset Crohn disease.

• Reviewing:
• Glocker E-O et al., N Engl J Med 2009 Nov 19; 361:2033 Kelsall B., N Engl J Med 2009 Nov 19; 361:2091

SUMMARY AND COMMENT

Does Chronic Hepatitis B Therapy Improve Long-Term Outcomes?

• November 20, 2009
• Atif Zaman, MD, MPH

Treatment that resulted in biochemical or histologic response was associated with improved long-term outcomes.

• Reviewing:
• Wong VW-S et al., Clin Gastroenterol Hepatol 2009 Oct; 7:1113

SUMMARY AND COMMENT

Transjugular Intrahepatic Portosystemic Shunts for Cirrhotic Patients

• November 20, 2009
• Atif Zaman, MD, MPH

Among patients who underwent TIPS placement, diastolic dysfunction was associated with slower ascites clearance and higher mortality.

• Reviewing:
• Rabie RN et al., Am J Gastroenterol 2009 Oct; 104:2458

SUMMARY AND COMMENT

Pancreatic Cancer and Gene Mutations for Lynch Syndrome

• November 13, 2009
• Stuart Sherman, MD

Compared with the general population, families with mutations had significantly greater cancer risk.

• Reviewing:
• Kastrinos F et al., JAMA 2009 Oct 28; 302:1790

SUMMARY AND COMMENT

The Cause of Primary Biliary Cirrhosis?

• November 13, 2009
• Atif Zaman, MD, MPH

Space–time clustering analysis of PBC cases suggests that a transient environmental agent is associated with development of the disease.

• Reviewing:
• McNally RJQ et al., Hepatology 2009 Oct; 50:1169

SUMMARY AND COMMENT

Does Green Tea Lower Risk for Gastric Cancer?

• November 13, 2009
• David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Results showing diminished risk for women who drink 5 cups per day are questionable.

• Reviewing:
• Inoue M et al., Gut 2009 Oct; 58:1323

SUMMARY AND COMMENT

Histological Disease in Chronic Hepatitis B Patients

• November 13, 2009
• Atif Zaman, MD, MPH

Among patients with normal ALT levels and high viral loads, those older than 35 or with fluctuating ALT levels were more likely to experience clinically significant disease.

• Reviewing:
• Nguyen MH et al., Am J Gastroenterol 2009 Sep; 104:2206

SUMMARY AND COMMENT

Viramidine vs. Ribavirin for Hepatitis C Infection

• November 6, 2009
• Atif Zaman, MD, MPH

The ribavirin prodrug viramidine failed to demonstrate noninferiority to ribavirin in achieving sustained virologic response rates.

• Reviewing:
• Benhamou Y et al., Hepatology 2009 Sep; 50:717

SUMMARY AND COMMENT

Missed Opportunities to Detect Colorectal Cancer

• November 6, 2009
• Douglas K. Rex, MD

Prior opportunities for diagnostic evaluations were missed in nearly one third of patients with newly diagnosed CRC.

• Reviewing:
• Singh H et al., Am J Gastroenterol 2009 Oct; 104:2543