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Search for Hepatitis in Gastroenterology
Physician-authored summaries on the latest research on hepatitis, editorials on hepatitis, and perspectives on hepatitis - drawn from the top medical journals.
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You searched for: hepatitis in Gastroenterology
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High Hepatitis B Surface Antigen Level Increases Risk for Hepatocellular Carcinoma
- May 4, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
The finding was for patients with a low hepatitis B virus DNA level.- Reviewing:
- Tseng T-C et al., Gastroenterology 2012 May; 142:1140.
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New Tests Predict Clinical Outcomes in Chronic Hepatitis C Virus Free
- May 4, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
A battery of quantitative liver-function tests might provide a noninvasive method of risk assessment.- Reviewing:
- Everson GT et al., Hepatology 2012 Apr; 55:1019.
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Highlights from the Conference on Chronic Viral Hepatitis Infection Free
- January 27, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
Medical models that improve screening and effectiveness of treatment in the community setting are required to reduce the disease burden.- Reviewing:
- Ward JW et al., Hepatology 2012 Jan; 55:307.
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Acute Kidney Injury Predicts Mortality in Acute Alcoholic Hepatitis
- January 27, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
New criteria for renal failure are superior to traditional criteria in predicting 90-day mortality and should be put to use in clinical settings.- Reviewing:
- Altamirano J et al., Clin Gastroenterol Hepatol 2012 Jan; 10:65.
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New Antivirals Show Promise for an Interferon-Free Hepatitis C Treatment
- January 18, 2012
- Atif Zaman, MD, MPH
- Gastroenterology
Patients with HCV genotype 1 and previous null response achieved a 36% sustained virologic response at 24 weeks of therapy with daclatasvir and asunaprevir alone.- Reviewing:
- Lok AS et al., N Engl J Med 2012 Jan 19; 366:216. Chung RT., N Engl J Med 2012 Jan 19; 366:273.
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Drug-Induced Liver Injury — Or Hepatitis E Virus Infection?
- December 9, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Acute HEV infection is a small but important cause of liver injury that is suspected to be drug induced.- Reviewing:
- Davern TJ et al., Gastroenterology 2011 Nov; 141:1665.
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Histologic Features Can Differentiate Drug-Induced Liver Injury from Autoimmune Hepatitis
- December 2, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Investigators report progress in using histologic data to more accurately distinguish between the two conditions.
CME Exam- Reviewing:
- Suzuki A et al., Hepatology 2011 Sep; 54:931.
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Emerging Treatment Options for Severe Acute Alcoholic Hepatitis
- November 10, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Adding N-acetylcysteine to glucocorticoid therapy did not improve 6-month survival. Early liver transplant did, but in a selectively chosen subgroup.
CME Exam- Reviewing:
- Nguyen-Khac E et al., N Engl J Med 2011 Nov 10; 365:1781. Mathurin P et al., N Engl J Med 2011 Nov 10; 365:1790. Brown RS Jr., N Engl J Med 2011 Nov 10; 365:1836.
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Child-Pugh Score Predicts Prognosis in Hepatitis C Virus Infection
- October 7, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Disease progression accelerates when Child-Pugh scores are ≥7.
CME Exam- Reviewing:
- Dienstag JL et al., Hepatology 2011 Aug; 54:396.
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Lamivudine for Chronic Hepatitis B Virus Infection
- May 6, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Switching from entecavir to lamivudine led to more viral rebound and drug resistance in patients who first achieved undetectable HBV DNA levels with entecavir.- Reviewing:
- Fung J et al., Hepatology 2011 Apr; 53:1148.
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Alternatives to Biopsy for Prognosis of Patients with Chronic Hepatitis C Infection
- April 29, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Noninvasive tests for liver stiffness and degree of fibrosis accurately predicted survival.- Reviewing:
- Vergniol J et al., Gastroenterology 2011 Mar 2;:
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Low-Dose Peginterferon as Maintenance Therapy for Hepatitis C-Infected Patients with Cirrhosis
- April 22, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Peginterferon alfa-2b did not prolong time to first occurrence of either clinical decompensation, hepatocellular carcinoma, liver transplant, or death.- Reviewing:
- Bruix J et al., Gastroenterology 2011 Mar 18;:
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Triple Therapy for Chronic Hepatitis C Virus Infection Free
- March 30, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Adding boceprevir to standard peginterferon and ribavirin therapy dramatically improved sustained virologic response.- Reviewing:
- Poordad F et al., N Engl J Med 2011 Mar 31; 364:1195. Bacon BR et al., N Engl J Med 2011 Mar 31; 364:1207. Jensen DM., N Engl J Med 2011 Mar 31; 364:1272.
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Is Liver Biopsy Necessary to Diagnose Autoimmune Hepatitis?
- March 11, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
The contribution of histologic data to the determination of AIH status is minimal.- Reviewing:
- Björnsson E et al., Clin Gastroenterol Hepatol 2011 Jan; 9:57.
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Tenofovir for HIV and Hepatitis B Virus Coinfection
- February 18, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
Long-term use of tenofovir as part of antiretroviral therapy was safe and effective in reducing HBV DNA levels.
CME Exam- Reviewing:
- de Vries-Sluijs TEMS et al., Gastroenterology 2010 Dec; 139:1934.
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Peginterferon, Adefovir, or Both for Chronic Hepatitis Delta Virus Infection
- February 4, 2011
- Atif Zaman, MD, MPH
- Gastroenterology
A 48-week regimen of peginterferon alfa-2a achieved HDV RNA clearance in more than 25% of patients, whereas adefovir had no effect.- Reviewing:
- Wedemeyer H et al., N Engl J Med 2011 Jan 27; 364:322.
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Pegylated Interferon-Lambda for Chronic Hepatitis C Virus Infection
- December 22, 2010
- David A. Johnson, MD
- Gastroenterology
In a phase Ib study, PEG-IFN-λ showed promise in both treatment-naive and relapsing patients.- Reviewing:
- Muir AJ et al., Hepatology 2010 Sep; 52:822.
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Budesonide for Autoimmune Hepatitis Free
- December 17, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
Budesonide was superior to prednisone at inducing remission with fewer steroid-specific adverse effects.- Reviewing:
- Manns MP et al., Gastroenterology 2010 Oct; 139:1198.
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Taribavirin vs. Ribavirin for Chronic Hepatitis C Virus Infection
- December 17, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
Virologic response rates were similar with both regimens; anemia was less common with taribavirin.- Reviewing:
- Poordad F et al., Hepatology 2010 Oct; 52:1208.
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An Interferon-Free Regimen for Chronic Hepatitis C Virus Infection
- November 19, 2010
- Atif Zaman, MD, MPH
- Gastroenterology
Combining a protease inhibitor and a polymerase inhibitor led to declines in viral load, even among patients with previous treatment failure.- Reviewing:
- Gane EJ et al., Lancet 2010 Oct 30; 376:1467.
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