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Search for Cirrhosis in Gastroenterology
Physician-authored summaries on the latest research on cirrhosis, editorials on cirrhosis, and perspectives on cirrhosis - drawn from the top medical journals.
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Identifying Cirrhosis in Patients with Hemochromatosis
- May 8, 2009
- Atif Zaman, MD, MPH
When combinations of other markers failed, a specific concentration of hyaluronic acid paired with serum ferritin levels >1000 µg/L correctly identified cirrhosis in patients with hereditary hemochromatosis.- Covering:
- Crawford DHG et al., Hepatology 2009 Feb; 49:418.
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Regression of Cirrhosis in HCV
- November 21, 2008
- Atif Zaman, MD, MPH
Study findings suggest that HCV treatment can lead to regression of cirrhosis. CME Exam- Covering:
- Mallet V et al., Ann Intern Med 2008 Sep 16; 149:399.
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Hepatitis B Viral Load Predicts Cirrhosis Risk
- June 13, 2006
- Atif Zaman, MD, MPH
Patients with higher viral loads are at higher risk for cirrhosis, independent of ALT level and HBeAg status.- Covering:
- Iloeje UH et al., Gastroenterology 2006 Mar; 130:678-86.
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Long-Acting Octreotide Reduces Portal Pressure in Patients with Cirrhosis
- August 30, 2007
- Atif Zaman, MD, MPH
In a small study, monthly intramuscular injections of octreotide resulted in significant reductions in portal hypertension. CME Exam- Covering:
- Spahr L et al., Am J Gastroenterol 2007 Jul; 102:1397-405.
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Interferon Therapy Improves Outcomes in HCV Patients with Cirrhosis
- June 1, 2007
- Atif Zaman, MD, MPH
Clinical endpoints were evaluated in a group of cirrhotic patients with well-compensated disease. CME Exam- Covering:
- Bruno S et al., Hepatology 2007 Mar; 45:579-87.
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Adefovir and Entecavir Are Cost-Effective in Patients with HBV-Related Cirrhosis
- December 8, 2006
- Atif Zaman, MD, MPH
Although adefovir and entecavir are more expensive than lamivudine, they are more cost-effective in this population.- Covering:
- Kanwal F et al., Am J Gastroenterol 2006 Sep; 101:2076-89.
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Natural History of Hepatitis C–Related Cirrhosis
- October 6, 2006
- Atif Zaman, MD, MPH
This long-term study of 214 untreated patients provides valuable data that will be useful in counseling patients.- Covering:
- Sangiovanni A et al., Hepatology 2006 Jun; 43:1303-10.
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Can Platelet Count Indicate Risk for Varices?
- March 28, 2008
- Atif Zaman, MD, MPH
Researchers studied the usefulness of changes in platelet count to predict gastroesophageal varices in patients with cirrhosis and portal hypertension.- Covering:
- Qamar AA et al., Hepatology 2008 Jan; 47:153.
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Small Arterial Phase-Enhancing Hepatic Lesions Usually Are Benign
- August 30, 2005
- Atif Zaman, MD, MPH
Current guidelines advise that patients with cirrhosis undergo screening for hepatocellular carcinoma. Quite frequently, small arterial phase-enhancing lesions are encountered during screening with computed tomography . . .- Covering:
- O’Malley ME et al., Am J Gastroenterol 2005 Jul; 100:1523-8.
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Natural History of Nonalcoholic Fatty Liver DiseaseFree!
- January 19, 2007
- Atif Zaman, MD, MPH
NASH does progress to cirrhosis, but only in a minority of cases. CME Exam- Covering:
- Ekstedt M et al., Hepatology 2006 Oct; 44:865-73.
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Effect of Hepatocellular Carcinoma Surveillance on Survival
- January 5, 2007
- Atif Zaman, MD, MPH
Among patients with cirrhosis, surveillance can lead to early detection of HCC and thereby lengthen survival.- Covering:
- Toyoda H et al., Clin Gastroenterol Hepatol 2006 Sep; 4:1170-6.
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Slow Rate of Disease Progression in HCV-Positive Women
- October 25, 2005
- Atif Zaman, MD, MPH
In a cohort of young women with known dates of infection, rates of long-term progression to fibrosis or cirrhosis were low.- Covering:
- Wiese M et al., J Hepatol 2005 Oct; 43:590-8.
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Combination Therapy vs. Monotherapy for Variceal Rebleeding
- September 19, 2008
- Atif Zaman, MD, MPH
The combination of endoscopic and beta-blocker therapy is more effective in reducing rebleed rates than is either therapy alone, but it does not improve survival. CME Exam- Covering:
- Gonzalez R et al., Ann Intern Med 2008 Jul 15; 149:109.
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Irbesartan for Treatment of Portal Hypertension?Free!
- August 22, 2008
- Atif Zaman, MD, MPH
Adding this angiotensin II–receptor antagonist to propranolol does not further reduce hepatic venous pressure gradient.- Covering:
- Schepke M et al., Am J Gastroenterol 2008 May; 103:1152.
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Predicting Hepatic Decompensation in Cirrhotic Patients
- October 5, 2007
- Atif Zaman, MD, MPH
Patients with hepatic venous pressure gradient measurements of <10 mm Hg were at low risk for developing decompensation within 4 years. CME Exam- Covering:
- Ripoll C et al., Gastroenterology 2007 Aug; 133:481.
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Variability of INR and Its Effect on MELD Scores
- September 21, 2007
- Atif Zaman, MD, MPH
Whether standard INR measurements are reliable and reproducible in patients with liver disease has been questioned.- Covering:
- Tripodi A et al., Hepatology 2007 Aug; 46:520.
- Bellest L et al., Hepatology 2007 Aug; 46:528.
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Using Liver Stiffness to Measure Portal Hypertension Noninvasively
- August 3, 2007
- Atif Zaman, MD, MPH
Transient elastography could be a noninvasive way of identifying cirrhotic patients with clinically significant portal hypertension.- Covering:
- Vizzutti F et al., Hepatology 2007 May; 45:1290-7.
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Maintenance Interferon Therapy for Patients with Chronic Hepatitis C Infections
- July 27, 2007
- Atif Zaman, MD, MPH
Two years of maintenance monotherapy in high-risk HCV-positive cirrhotic patients is ineffective for lengthening complication-free survival. CME Exam- Covering:
- Fartoux L et al., Clin Gastroenterol Hepatol 2007 Apr; 5:502-7.
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Preventing Bacterial Infections in Cirrhotic Patients with Gastrointestinal Hemorrhage
- February 9, 2007
- Atif Zaman, MD, MPH
Intravenous ceftriaxone is superior to oral norfloxacin in acute settings. CME Exam- Covering:
- Fernández J et al., Gastroenterology 2006 Oct; 131:1049-56.
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Balloon-Occluded Retrograde Transvenous Obliteration for Preventing Gastric Variceal Hemorrhage
- March 14, 2006
- Atif Zaman, MD, MPH
This technique was effective for preventing primary bleeding in a small nonrandomized trial.- Covering:
- Takuma Y et al., Clin Gastroenterol Hepatol 2005 Dec; 3:1245-52.
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