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Gastroenterology
Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
Magnifying Narrow-Band Imaging Improves the Diagnosis of Gastric Mucosal CancerFree
- January 20, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
Better than standard white light but still not as good as a biopsy
- Reviewing:
- Ezoe Y et al. Gastroenterology 2011 Dec; 141:2017
Special Notice
Gut Check on Gastroenterology Blog Post: Stewardship in Medicine
Now that we have technologies that exceed the threshold for identifying polyp histology established by the ASGE, Dr. M. Brian Fennerty wonders if it’s it's time to stop sending small colorectal polyps to the pathologist. What do you think?
Recent Gastroenterology Articles
SUMMARY AND COMMENT
Colorectal Cancer Risk Higher After Adenoma Removal
- January 20, 2012
- Douglas K. Rex, MD
People who had undergone adenoma removal had a higher risk for colorectal cancer than the general population.
- Reviewing:
- Cottet V et al. Gut 2011 Nov 22
SUMMARY AND COMMENT
New Antivirals Show Promise for an Interferon-Free Hepatitis C Treatment
- January 18, 2012
- Atif Zaman, MD, MPH
Patients with HCV genotype 1 and previous null response achieved a 36% sustained virologic response at 24 weeks of therapy with daclatasvir and asunaprevir alone.
- Reviewing:
- Lok AS et al. N Engl J Med 2012 Jan 19; 366:216
SUMMARY AND COMMENT
A New Four-Drug Regimen for H. pylori Infection?
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
Eradication was better than with standard triple therapy.
- Reviewing:
- Basu PP et al. Am J Gastroenterol 2011 Nov; 106:1970
SUMMARY AND COMMENT
Sequential Therapy Bests Triple Therapy for H. pylori Infection
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
Eradication rates were higher; adverse events were similar.
- Reviewing:
- Kim YS et al. Aliment Pharmacol Ther 2011 Nov; 34:1098
SUMMARY AND COMMENT
Add Parasites to the Causes of Postinfectious Irritable Bowel Syndrome!
- January 13, 2012
- Douglas K. Rex, MD
IBS and chronic fatigue were more common in patients who had previously contracted giardiasis than in population controls.
- Reviewing:
- Wensaas K-A et al. Gut 2012 Feb; 61:214
SUMMARY AND COMMENT
Can Antibiotics Induce Inflammatory Bowel Disease?
- January 13, 2012
- Douglas K. Rex, MD
Use of these medications, which alter gut flora, might be a predisposing factor. CME
- Reviewing:
- Shaw SY et al. Am J Gastroenterol 2011 Dec; 106:2133
SUMMARY AND COMMENT
Cytomegalovirus in Inflamed Tissue Predicts Treatment Failure in Ulcerative Colitis
- January 13, 2012
- Douglas K. Rex, MD
The rate of response to treatment was 38% in patients who had CMV DNA detected versus 100% in those who did not.
- Reviewing:
- Roblin X et al. Am J Gastroenterol 2011 Nov; 106:2001
SUMMARY AND COMMENT
NSAIDs and Statins Might Have Chemopreventive Potential for Barrett EsophagusFree
- January 13, 2012
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
In an observational study, use of the two drugs together greatly reduced the risk for neoplastic progression.
- Reviewing:
- Kastelein F et al. Gastroenterology 2011 Dec; 141:2000
SUMMARY AND COMMENT
Another Possible Fix for Low Adenoma Detection RatesFree
- January 13, 2012
- Douglas K. Rex, MD
Having an experienced nurse act as a second observer during colonoscopies performed by fellows could improve detection rates.
- Reviewing:
- Lee CK et al. Gastrointest Endosc 2011 Nov; 74:1094
SUMMARY AND COMMENT
What Do You Get for a Million FOBTs?
- January 13, 2012
- Douglas K. Rex, MD
In England, nearly 1800 colorectal cancers — most of them left-sided
- Reviewing:
- Logan RFA et al. Gut 2011 Dec 7
Editor's Picks from across Journal Watch
SUMMARY AND COMMENT
Genotype Testing for Clopidogrel Responsiveness May Not Predict Events
- January 4, 2012
- By Howard C. Herrmann, MD
- Cardiology
A meta-analysis finds no association between CYP2C19 genotype and cardiovascular outcomes in clopidogrel recipients, but concerns about stent thrombosis linger.
- Reviewing:
- JAMA 2011 Dec 28; 306:2704
SUMMARY AND COMMENT
Does Anti–Tumor Necrosis Factor α Therapy Increase the Risk for Serious Infection?
- November 10, 2011
- By Jeffrey P. Callen, MD
- Dermatology
In this large cohort study, unlike in most of the previous studies, researchers found no increased risk for serious infections with TNF antagonists.
- Reviewing:
- JAMA 2011 Nov 6
SUMMARY AND COMMENT
Antiplatelet Therapy for Atrial Fibrillation: One Drug or Two?
- December 7, 2011
- By Joel M. Gore, MD
- Cardiology
In an ACTIVE substudy, the net clinical benefit of adding clopidogrel to aspirin in patients who were not candidates for warfarin was small and statistically nonsignificant.
- Reviewing:
- Ann Intern Med 2011 Nov 1; 155:579
SUMMARY AND COMMENT
When Is Dabigatran More Cost-Effective Than Warfarin?
- December 7, 2011
- By Mark S. Link, MD
- Cardiology
For patients with nonvalvular atrial fibrillation who are not well-controlled on warfarin, the 150-mg dose of dabigatran can be a cost-effective choice for stroke prevention.
- Reviewing:
- BMJ 2011 Oct 31; 343:d6333
Journal Watch Gastroenterology summarizes important medical journal articles about a wide variety of GI subjects including cirrhosis, dyspepsia, gastric cancer, GERD, H. pylori, and hepatitis.
