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Gastroenterology
Journal Watch condenses summaries of key research across specialties from more than 250 medical journals into concise yet comprehensive articles, incorporating clinical commentary from prominent physician-editors in the field.
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Featured Article
SUMMARY AND COMMENT
Sofosbuvir Works for Patients Who Cannot Take PeginterferonFree
- May 24, 2013
- Atif Zaman, MD, MPH
Two phase III studies confirm the efficacy of a sofosbuvir and ribavirin therapy in patients with HCV genotype 2 or 3 infection for whom peginterferon is not an option.
- Reviewing:
- Jacobson IM et al. N Engl J Med 2013 May 16; 368:1867
Recent Gastroenterology Articles
SUMMARY AND COMMENT
Drug-Induced Liver Injury from TNF Antagonists
- May 24, 2013
- Atif Zaman, MD, MPH
The chance of injury resolution is good with drug discontinuation, but the mechanism is still unclear.
- Reviewing:
- Ghabril M et al. Clin Gastroenterol Hepatol 2013 May; 11:558
SUMMARY AND COMMENT
Postpolypectomy Syndrome in Detail
- May 24, 2013
- Douglas K. Rex, MD
A large, retrospective study focuses on symptoms, treatment, outcomes, and risk factors.
- Reviewing:
- Cha JM et al. Endoscopy 2013 Mar; 45:202
SUMMARY AND COMMENT
Return of Peristalsis After Myotomy for Achalasia?
- May 24, 2013
- David A. Johnson, MD
Partial recovery of peristalsis did occur after laparoscopic or endoscopic myotomy in more than half of patients, but larger studies are needed.
- Reviewing:
- Roman S et al. JAMA Surg 2013 Feb; 148:157
SUMMARY AND COMMENT
Treating GERD Successfully: Beyond Heartburn ReliefFree
- May 17, 2013
- David A. Johnson, MD
A short questionnaire helps identify whether patients on therapy for GERD are experiencing sleep disturbance and might benefit from an adjustment in therapy.
- Reviewing:
- Moayyedi P et al. Aliment Pharmacol Ther 2013 Apr; 37:730
SUMMARY AND COMMENT
Use Ciprofloxacin with Adalimumab for Perianal Crohn Disease
- May 17, 2013
- Douglas K. Rex, MD
At least half of draining fistulas closed in 71% of patients randomized to combination therapy versus 47% with anti-TNF therapy alone.
- Reviewing:
- Dewint P et al. Gut 2013 Mar 23
SUMMARY AND COMMENT
Predictors of Poor Outcomes in Autoimmune Hepatitis
- May 17, 2013
- Atif Zaman, MD, MPH
Liver-related death or need for liver transplantation was associated with age at presentation, incomplete treatment response, and low albumin, but not advanced fibrosis.
- Reviewing:
- Ngu JH et al. Hepatology 2013 May 1
SUMMARY AND COMMENT
PEG Can Cause Renal Failure, Too
- May 17, 2013
- Douglas K. Rex, MD
Although safer than sodium phosphate, polyethylene glycol solution can also put patients at risk for acute renal failure.
- Reviewing:
- Choi NK et al. Endoscopy 2013 Mar; 45:208
FEATURE
FDA: Fecal Transplants Need Investigational New Drug ApplicationFree
- May 13, 2013
- HIV/AIDS Clinical Care
In his blog HIV and ID Observations, Dr. Paul Sax weighs in on a recent FDA decision regarding fecal microbiota transplantation.
MEDICAL NEWS
FDA Expands Indications for Simponi to Ulcerative ColitisFree
- May 17, 2013
- Physician's First Watch
Golimumab (Simponi) has been approved to treat adults with moderate-to-severe ulcerative colitis that has not responded to other treatment or that requires ongoing...
SUMMARY AND COMMENT
Early Capsule Endoscopy for Overt Obscure Gastrointestinal BleedingFree
- May 10, 2013
- David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)
Procedures performed within 3 days of hospital admission were associated with higher diagnostic yield, more therapeutic interventions, and shorter stays.
- Reviewing:
- Singh A et al. Gastrointest Endosc 2013 May; 77:761
Editor's Picks from across Journal Watch
CLINICAL PRACTICE GUIDELINE WATCH
Prostate Cancer Screening: One More Take
- April 11, 2013
- By Allan S. Brett, MD
- General Medicine
The American College of Physicians has issued guidance for clinicians.
- Reviewing:
- Ann Intern Med 2013 Apr 9
PATIENT INFORMATION
Vitamin D and Calcium: What Women Need at Midlife and After
- February 28, 2013
- By Diane E. Judge, APN/CNP
- Women's Health
Both nutrients are important for bone health.
SUMMARY AND COMMENT
Midlife Cardiorespiratory Fitness Might Attenuate Later-Life Dementia
- March 19, 2013
- By Jamaluddin Moloo, MD, MPH
- General Medicine
Later dementia was less common among people who were more fit before age 65.
- Reviewing:
- Ann Intern Med 2013 Feb 5; 158:162
SUMMARY AND COMMENT
Intensive Life Support After Major Surgery: The Surgeon's Perspective
- March 12, 2013
- By Patricia Kritek, MD
- General Medicine
Many surgeons believe that withdrawing life support during the first postoperative week is unacceptable. Interview
- Reviewing:
- JAMA Surg 2013 Jan; 148:29
Journal Watch Gastroenterology summarizes important medical journal articles about a wide variety of GI subjects including cirrhosis, dyspepsia, gastric cancer, GERD, H. pylori, and hepatitis.
